Garry: I think that getting into show business comes from some core dysfunction where you say, "I want to be seen."
Jerry: Or god forbid maybe you have some talent. God forbid maybe it's not all yawning chasms of human insecurity. Is it possible someone out there has some talent? And maybe they want to express that for the betterment of mankind!?
Garry: I think I hear rage.
Shandling's response (at :35) is just so goddamn perfect. Comedy, life, and the whole shebang. Shandling's WTF is amazing too btw.
In Sick in the Head: Conversations About Life and Comedy, Judd Apatow discusses this exchange (via MK) like this:
Judd: In personality, it’s different. There are some guys who are kind of smart and witty and funny, and there are some guys who are just a little bit off, and there’s some guys who clearly got a beat-down at some point during their young life and that made them feel the need to get attention.
Charlie: And so which one is he?
Adam: So many of those.
Charlie: All of the above.
Judd: There is a moment on Garry Shandling’s DVD commentary for The Larry Sanders Show where he talks about this with Jerry Seinfeld and Jerry Seinfeld says to Garry, “Why can’t you be a comedian just because you’re talented and you’re smart and that’s why you’re a comedian?”
Charlie: That’s what I would ask, yes.
Judd: And Garry just goes, “Why so angry, Jerry?” I think that captures it.
Ya can also check out "The 12 Best Stories, From Stephen Colbert to Amy Schumer, in Judd Apatow’s Book Sick in the Head" [Vulture].
And here's the Phil Hartman acting coach sketch that Seinfeld raves about later in that video.