Above is his intro to the movie and some questions afterwards. Good quote from about 3min in:
I don't get scared to say anything anymore. As long as it feels real to me. As long as it feels like a real thought that I can believe in and defend, I go ahead and say it. It doesn't occur to me anymore that it's not a good idea as long as I really do think it.
In this part (at 2:30 in or so), someone asks Louis if he's ever offended by his own jokes. A: Yeah, by jokes that are too easy.
There are bits that I have done that have killed that I stopped doing because I don't like them. They don't feel real. I just used "joke technology"...I hate how easily they work and how predictable they are. So I stopped doing them.
I like that phrase "joke technology." How I interpret it: The way you can get a laugh from a certain structure or misdirection, but it feels hollow because there's no real feeling there.
In this last clip, he ends by doing a bit in progress that wonders if maybe we shouldn't get so mad at kid fuckers. Great. [Thx NC]