In the hands of most people, I couldn't give a shit. But the exception that shows how you can still take an innovative approach to a topic like that is Patton Oswalt's bit on meeting George Lucas and discussing the prequels. Read the bit or listen to it.
"Would you like a dish of ice cream?"
"Why, yes I would l like some ice cream. That would be very nice!"
"Well here's a big sack of rock salt!"
"What? You said I'd be getting ice cream?"
"Well, when you add the cream and sugar and ice and do a little mixing and then presto, you have ice cream!"
"I DON'T GIVE A SHIT WHERE THE STUFF I LOVE COMES FROM! I JUST LOVE THE STUFF I LOVE! Hey, do you love Angelina Jolie? Does she give you a big boner? Well then here's Jon Voight's ballsack! That's right! The sweaty, pink ballsack she swam out of. Now jerk off to that, you lucky so and so!"
I've never even seen any of the prequels yet I still think it's hilarious. Goes to show that if you take a fresh enough approach, you can talk about anything. Plus, ya can really tell that Patton feels passionately about it. When you care deeply about a subject, you can take it to a place that other comics won't be able to reach.
Mo Diggs also mentions another good exception: John Mulaney's bit on the characters in Law and Order. It is pretty great. Again, Mulaney really does seem obsessed with the show which helps. In the hands of a lesser standup, it'd fall flat.
I stick by the original point though. If you constantly talk about TV, you probably aren't a very interesting person. And if you're not an interesting person, it's tough to be a good standup.